"I'm only running the 200m here," said Jackson, the double world 200-metre champion, who has won silvers in the 100m in the last two world champs and Olympic 100m bronze at the Tokyo Games.
"I think it was a good decision," the 30-year-old said of her desire to focus on the 200m.
"Coach and I made a decision, and it was in the best interests for both of us."
But Jackson's announcement does come in the wake of her pulling up with an apparent injury late in a race in Hungary three weeks ago.
The Jamaican was leading the race entering the home straight before abruptly slowing down, grimacing and putting her head in her hands as she eventually walked across the finish line.
"It's a combination of things," Jackson said of her decision.
"I got hurt in Hungary and it's a good decision to run one event."
Round one of the women's 100m at the Paris Olympics is scheduled for Friday at the Stade de France.
The semi-finals and final are programmed for Saturday.
The opening round for the 200m is due on Sunday, with the semi-finals a day later and the final on Tuesday.
Jackson's teammate Elaine Thompson-Herah won both the 100 and 200m at the Tokyo Olympics.
