Pakistan had been well-placed at 59-0 in the sixth over of this fourth T20 of a rain-marred series -- the matches at Headingley and Cardiff were washed out without a ball bowled after losing the toss in gloomy conditions at south London.
But they slumped to 86-5 in a collapse that started when captain Babar Azam was out for a well-made 36.
Azam, having struck Jofra Archer for successive fours, was caught next ball at slip off the express quick.
Adil Rashid took 2-27 from his maximum four overs, with fellow spinner Liam Livingstone striking twice in an over.
Fast bowler Mark Wood also took two wickets with well-directed bouncers.
After a brief rain break, Usman Khan repaired some of the damage with a brisk 38 that took Pakistan to 126-6.
But he was superbly caught low down by Chris Jordan off Livingstone when England's best fielder ran in from long-on.
Jos Buttler was leading England after his wife gave birth to the couple's third child following his dashing 84 in the hosts' 23-run win in the second T20 at Edgbaston.
