The 33-year-old played a big role for England at the 2024 European Championships but has called time on his international career.
Trippier was a staple of the England squad throughout the country's most successful period in over 20 years and is part of an exclusive list of players to score for the Three Lions in a World Cup semi-final.
Announcing his retirement on Instagram, the defender said: "I never thought as a young lad from Bury that I would play for my country let alone achieve 54 caps.
"It's been one of the biggest honours of my life to represent my country at four major tournaments.
"A big thank you to all the England fans for your incredible support travelling all over the world to support us and keeping us going in the difficult moments."
Interim manager Lee Carsley is due to reveal his first England squad later on Thursday afternoon - although it won't feature Trippier.
