Cardiff sacked manager Erol Bulut on Monday after a dismal start to the Championship season left the Welsh club bottom of the table.
Saturday's 2-0 home defeat to Leeds left the Bluebirds with just one point from their opening six matches, having scored just one goal and conceded 13.
In a short statement, the club confirmed Bulut "has been relieved of his duties and will leave the club with immediate effect".
Bulut had been handed a two-year contract extension in June after leading Cardiff to a 12th-placed finish in his first season in charge.
Omer Riza will take charge on an interim basis.