Saudi target Mitrovic out of Fulham's home derby with Brentford
Mitrovic has three years left on his contract but has attracted interest from Saudi Arabia, with the West Londoners last month reportedly rejecting a 25 million pound bid from Pro League side Al Hilal.
British media have indicated Riyadh-based Al Hilal have since come back with a greatly improved offer of around 46 million pounds.
"Just Mitrovic is going to be out of the game, all the other players are going to be ready," Silva told reporters on Friday.
"He's out of the game because he had a problem in his ankle in the last game, he is not working with his teammates because of the injury."
Silva said he had no information about a bid for the Serb being accepted.
"The injury is not going to be something serious where he will be out of competition for three, four weeks," added the Portuguese.
Mitrovic, Fulham's top scorer in four of the last five seasons, was a second-half substitute in Fulham's opening 1-0 win at Everton.