Who's Missing: Man Utd head to rivals City without eight key players
Meanwhile, Liverpool boss Jurgen Klopp will hope his youngsters can continue outperforming expectations in place of some injured regular starters, while West Ham head to Everton looking in ship shape condition.
Take a look at who's missing from the upcoming round of Premier League fixtures:
Brentford v Chelsea - Saturday, 15:00 GMT
WILL NOT PLAY
Dasilva J. (Knee Injury)
Henry R. (Knee Injury)
Hickey A. (Thigh Injury)
Mbeumo B. (Ankle Injury)
Pinnock E. (Ankle Injury)
Schade K. (Hip Injury)
WILL NOT PLAY
Badiashile B. (Groin Injury)
Chukwuemeka C. (Knee Injury)
Cucurella M. (Ankle Injury)
Fofana W. (Knee Injury)
James R. (Thigh Injury)
Lavia R. (Injury)
Nkunku C. (Injury)
Ugochukwu L. (Thigh Injury)
QUESTIONABLE
Silva T. (Groin Injury)
Everton v West Ham - Saturday, 15:00 GMT
WILL NOT PLAY
Alli D. (Muscle Injury)
Danjuma A. (Ankle Injury)
QUESTIONABLE
Gomes A. (Calf Injury)
WILL NOT PLAY
None
Fulham v Brighton - Saturday, 15:00 GMT
WILL NOT PLAY
Jimenez R. (Thigh Injury)
Palhinha J. (Yellow Cards)
QUESTIONABLE
Willian (Injury)
WILL NOT PLAY
Gilmour B. (Red Card)
Hinshelwood J. (Ankle Injury)
Joao Pedro (Thigh Injury)
March S. (Knee Injury)
Milner J. (Knee Injury)
Mitoma K. (Back Injury)
QUESTIONABLE
Ferguson E. (Ankle Injury)
Veltman J. (Injury)
Newcastle v Wolves - Saturday, 15:00 GMT
WILL NOT PLAY
Joelinton (Thigh Injury)
Pope N. (Shoulder Injury)
Targett M. (Injury)
Tonali S. (Suspended)
Wilson C. (Chest Injury)
WILL NOT PLAY
Cunha M. (Thigh Injury)
Nottingham Forest v Liverpool - Saturday, 15:00 GMT
WILL NOT PLAY
Aina O. (Injury)
Boly W. (Injury)
Sangare I. (Injury)
Tavares N. (Injury)
Wood Ch. (Thigh Injury)
WILL NOT PLAY
Alexander-Arnold T. (Knee Injury)
Alisson (Hamstring Injury)
Bajcetic S. (Calf Injury)
Diogo Jota (Knee Injury)
Gravenberch R. (Ankle Injury)
Jones C. (Calf Injury)
Matip J. (Knee Injury)
Thiago (Muscle Injury)
QUESTIONABLE
Endo W. (Ankle Injury)
Nunez D. (Injury)
Salah M. (Thigh Injury)
Szoboszlai D. (Knee Injury)
Tottenham v Crystal Palace - Saturday, 15:00 GMT
WILL NOT PLAY
Forster F. (Ankle Injury)
Porro P. (Muscle Injury)
Sessegnon R. (Thigh Injury)
Solomon M. (Knee Injury)
WILL NOT PLAY
Doucoure C. (Achilles Tendon Injury)
Guehi M. (Knee Injury)
Holding R. (Ankle Injury)
Olise M. (Muscle Injury)
Rak-Sakyi J. (Thigh Injury)
QUESTIONABLE
Eze E. (Thigh Injury)
Hughes W. (Ankle Injury)
Luton v Aston Villa - Saturday, 17:30 GMT
WILL NOT PLAY
Adebayo E. (Thigh Injury)
Andersen M. (Calf Injury)
Brown J. (Knee Injury)
Lockyer T. (Heart Problems)
Nakamba M. (Knee Injury)
WILL NOT PLAY
Buendia E. (Knee Injury)
Diego Carlos (Muscle Injury)
Duran J. (Injury)
Kamara B. (Knee Injury)
Konsa E. (Knee Injury)
Mings T. (Knee Injury)
Burnley v Bournemouth - Sunday, 13:00 GMT
WILL NOT PLAY
Beyer J. (Thigh Injury)
Brownhill J. (Red Card)
Foster L. (Injury)
Koleosho L. (Knee Injury)
Ramsey A. (Knee Injury)
Redmond N. (Muscle Injury)
WILL NOT PLAY
Aarons M. (Thigh Injury)
Adams T. (Thigh Injury)
Fredericks R. (Calf Injury)
Hill J. (Ankle Injury)
QUESTIONABLE
Kelly L. (Hip Injury)
Manchester City v Manchester United - Sunday, 15:30 GMT
WILL NOT PLAY
Gvardiol J. (Ankle Injury)
WILL NOT PLAY
Hojlund R. (Muscle Injury)
Maguire H. (Injury)
Malacia T. (Knee Injury)
Martial A. (Surgery)
Martinez Li. (Knee Injury)
Mount M. (Muscle Injury)
Shaw L. (Leg Injury)
Wan-Bissaka A. (Knock)
Sheffield United v Arsenal - Monday, 20:00 GMT
WILL NOT PLAY
TBD
QUESTIONABLE
TBD
WILL NOT PLAY
TBD
QUESTIONABLE
TBD
