Forest's Brennan Johnson accused Podence of spitting at him in the 90th minute but the incident was checked by VAR at the time and no action was taken against the Portuguese player.
Podence scored Wolves' equaliser in the match and the alleged incident near the final whistle occurred during a melee.
If found guilty, Podence would face a mandatory six-match suspension which would be a big blow to Wolves in their battle to avoid being sucked into the relegation zone.
The bad-tempered Midlands tussle also resulted in Forest being charged by the FA for allegedly failing to control their players after they surrounded the referee in the 40th minute.
Forest's assistant manager Alan Tate and his counterpart Pablo Sanz also face an FA charge for improper/violent conduct.
All those charged have until April 12 to respond.
