Martinez and Thuram star as Inter go four points clear at Lazio
Inter's dynamic attacking duo made sure their team took full advantage of closest rivals Juventus only drawing at Genoa on Friday to put daylight between Simone Inzaghi's side and the rest of the chasing pack.
The pair have scored 22 Serie A goals between them this term for Inter, who are gunning to beat local rivals AC Milan - nine points back after beating Monza 3-0 - to 20 league titles.
Inzaghi has never won the Scudetto as a coach but his team have been by far and away Italy's best over the 16 matches played so far and continued their charge at the Stadio Olimpico in Rome.
Martinez sent Inter on their way five minutes before the break by netting his 17th goal of a remarkable season to date, pouncing on a dreadful Adam Marusic backpass before skipping around Lazio goalkeeper Ivan Provedel and prodding home.
Lazio came out strong after the restart, Nicolo Rovella being denied by Yann Sommer after bursting into the box unopposed, but Thuram doubled the away side's lead in the 66th minute.
The France forward rolled home his eighth club goal of the season after being put through by Nicolo Barella.
That strike ended Lazio's resistance and left Maurizio Sarri's side 11th following a first home defeat since August, with Manuel Lazzari's late red card for dissent the icing on a bitter cake.
Bologna in top four
Bologna have been the revelation of the season so far and will finish the weekend fourth after an impressive 2-0 win against top-four rivals Roma.
Nikola Moro's 37th-minute strike and a Rasmus Kristensen own goal shortly after the break were enough for Bologna to claim their third win in four games and jump a point above champions Napoli and Fiorentina, who beat Verona 1-0 earlier in the day.
"We played football when we needed to and kept it tight, not allowing Roma to get into the game," said coach Thiago Motta to DAZN.
Motta has done a sensational job at Bologna after replacing Sinisa Mihajlovic in September last year, just over three months before his Serbian predecessor succumbed to leukaemia.
"I'm sure that Sinisa was watching over us, and giving us a hand," added Motta.
Mourinho, whose team missed key attackers Paulo Dybala and Romelu Lukaku, drop down to seventh, three points from Bologna.
"Without Paulo, there's no class, and without Romelu there's no physical presence," said Mourinho, who confirmed that he intends to stay at Roma next season.
"Without both at the same time I knew it would be hard for us."
Udinese are one point above the relegation zone after throwing away a two-goal lead to draw 2-2 with Sassuolo.