La Rochelle's Danty, 30, replaces Yoram Moefana, who is on the bench, after victory over Scotland in the last round.
Danty, a powerful ball-carrier, made the last of his 19 Test appearances in November and has played three club games since recovering from a knee injury.
"I bumped into Jonathan this morning and I said 'I'm sure the journalists are going to ask something about you. Do you have something to say?" Galthie told reporters.
"His response was short, he's said he was keen.
"With that he said everything. We understood all he needed to say," he added.
Tight-head prop Dorian Aldegheri comes in for the banned Mohamed Haouas and flanker Francois Cros takes the place of injured Anthony Jelonch for Saturday's game at Twickenham.
Les Bleus can still retain the Championship but need other results to go their way after victories over Italy and Scotland came either side of defeat to Ireland in round two.
France last won at Twickenham in 2007.
They will host this year's Rugby World Cup which starts on September 8.
Follow the match against England here with Flashscore.
France (15-1)
Thomas Ramos; Damian Penaud, Gael Fickou, Jonathan Danty, Ethan Dumortier; Romain Ntamack, Antoine Dupont (capt); Gregory Alldritt, Charles Ollivon, Francois Cros; Paul Willemse, Thibaud Flament; Dorian Aldegheri, Julien Marchand, Cyril Baille
Replacements: Peato Mauvaka, Reda Wardi, Sipili Falatea, Romain Taofifenua, Sekou Macalou, Maxime Lucu, Yoram Moefana, Melvyn Jaminet
Coach: Fabien Galthie (FRA)
