Howe concerned for Atsu's safety after Turkey earthquake
The coach of Atsu's Turkish club, Hatayspor, said earlier this week that the midfielder had not been found despite initial reports suggesting he had been rescued from the rubble.
A 7.8-magnitude quake hit Turkey and Syria early Monday, killing nearly 22,000 people in one of the region's worst disasters for a century.
Atsu, 31, who played under Howe on loan at Bournemouth before a five-year spell at Newcastle, has still not been found in the devastated region.
Asked on Friday about Atsu, who joined Hatayspor last year, Howe said: "It's hugely worrying. I really, really enjoyed working with Christian, a great lad, great player. Our thoughts are with him and his family.
"We hope for some good news, we hope he's OK, but we're really concerned for him and his welfare this week."
Howe said the conflicting stories about Atsu's safety following the disaster had made it even harder to handle such a distressing situation.
"It's been very tough," he said. "I can't imagine how his family are feeling. But from the bottom of our hearts, we wish him well and hope there's a positive ending."
Howe is preparing fourth-placed Newcastle for Saturday's match against struggling Bournemouth, the club at which he made his name as a manager during two spells.
The 45-year-old left the south-coast club following their relegation from the top flight at the end of the 2019/20 season.
"I always think there is a shelf life for a manager and I had probably reached that point where for the football club, I needed to move, really," he said.
"I definitely felt going into that last season. It was totally different, unique due to Covid, and the ending of that season was so disappointing."
Howe will have record signing Alexander Isak available after he missed last weekend's 1-1 draw with West Hamlast weekend's 1-1 draw with West Ham under concussion protocols.
But influential midfielder Bruno Guimaraes will sit out again as he serves the second instalment of his three-match ban.