Kazakhstan last September agreed a five-year deal for the Sokol International Racetrack outside Almaty to stage MotoGP races.
The inaugural race had been scheduled for July 9th as the ninth round.
"Ongoing homologation works at the circuit, paired with current global operational challenges, have obliged the cancellation of the 2023 event," MotoGP, the governing FIM and teams' body IRTA said in a joint statement.
They looked forward to racing there in 2024 instead.
MotoGP is keen to expand its presence in Asia, with India also set to debut in September with a race at the Buddh International Circuit near New Delhi.
The cancellation of Kazakhstan opens up a six-week break in the calendar between the Dutch TT on June 25th and the British Grand Prix on August 6th.
It also takes away a possible 37 points from the championship, with each race weekend now a double-scoring opportunity thanks to a sprint race every Saturday as well as the main Sunday event.
