Mott steps down as England white-ball coach after two years
England assistant coach Marcus Trescothick has been appointed on an interim basis to replace the Australian.
Since his appointment in May 2022, the 50-year-old Mott helped England win the T20 World Cup later that year and guided them to white-ball series wins over Australia, Bangladesh, Ireland, the Netherlands, New Zealand and Pakistan.
"I am immensely proud to have coached the England men's team; it has been an honour," Mott said in a statement.
"We have put everything into trying to achieve success over the past two years, and I am incredibly proud of the character and passion that the team has displayed during that period, including a magnificent T20 World Cup victory in 2022."
Former England batsman Trescothick will lead the team on an interim basis for the rest of the home summer, which includes a white-ball series against Australia in September.
"He (Mott) can be proud of his achievements as he leaves his post as one of only three coaches who have won a World Cup with England," said Rob Key, ECB managing director of England men's cricket.
"After three World Cup cycles in a short space of time, I now feel the team needs a new direction to prepare for the challenges ahead. This decision was not made lightly, but I believe it is the right time for the team's future success.
"The search for a full-time replacement will now begin. It is essential that we go through the right process to ensure we get the best person for the job."