The Spanish central defender revealed the decision to hang up his boots in a touching video posted to social media on Thursday evening.
"Culers, I have something to tell you. The last months, weeks, lots have been talking about me," Pique began.
"Until now, I haven't said anything. But now, I want to be the one talking about me. Like many of you, I've always been a Barca fan. I was born into a football-loving family of Barca fans.
"From a very young age, I did not want to become a football player, I wanted to play for Barca. I have been thinking a lot about that kid lately, about what little Gerard would have thought had all his dreams come true.
"That he would make it to the Barca first team, that he would win every trophy possible. That he would become a European champion and world champion. That he would play alongside some of the best players in history, and captain the club and make friends for life.
"It has been 25 years since I joined Barca, I left and I came back. Football has given me everything. I have always said that I would not be in any other team after I left Barca, and that is how it will be.
"This Saturday's game will be my last at Camp Nou. I will become a regular fan. I will support the team. I will pass my love for Barca to my children, like my family did with me. And you know me, sooner or later, I'll be back.
"I'll see at the Camp Nou. Long live Barca. Always."
Formerly of Manchester United, Pique has enjoyed a stellar 18-year playing career with the bulk of his near-800 appearances turning out in the heart of Barcelona's defence.
He hoisted 35 trophies in that time including the Premier League in England, eight Spanish LaLiga titles and winning the Champions League on four occasions.
Pique's success also translated on the international stage, helping Spain lift the World Cup in 2010 and the European Championship crown two years later.
