Ronaldo put his club woes behind him to open the scoring from the penalty spot, with Joao Felix and Rafael Leao also netting.
Ghana became their first AFCON nation to score at this year's World Cup, but it was in vein as their opponents proved too strong in the end.
See our as-it-happened updates below.
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90+11' That's the end of the match.
90+5' Bruno Fernandes (Portugal) commits a foul and is shown a yellow card without any hesitation from the referee.
90+2' Otto Addo decides to make a substitution. Mohammed Salisu will be replaced by Antoine Semenyo (Ghana).
90+2' It will be a substitution. Daniel-Kofi Kyereh (Ghana) is ready to enter the pitch as Salis Abdul Samed walks off.
90+1' Danilo Pereira (Portugal) receives a yellow card from the referee for a foul that he committed a little earlier.
90+1' Booking. Inaki Williams (Ghana) receives a caution from the referee.
89' 3 - 2
Osman Bukari (Ghana) leaps to connect with a delightful cross and places his sweet header inside the right post. The goalkeeper had no chance to make a save.
88' The referee signals a substitution. Joao Mario (Portugal) is brought on as a substitute for Joao Felix.
88' Fernando Santos has decided to make a change. Goncalo Ramos (Portugal) replaces Cristiano Ronaldo.
88' The game has come to an end for Bernardo Silva. He has contributed as much as he could today. He will be replaced by the fresh legs of Joao Palhinha (Portugal).
80' 3 - 1
Bruno Fernandes produces a sweet pass and picks out Rafael Leao (Portugal) inside the box. He quickly takes a shot which goes into the bottom right corner and leaves the goalkeeper helpless. He makes it 3:1!
78' 2 - 1
Joao Felix (Portugal) is released by Bruno Fernandes, he surges into the box and smashes a great shot into the top corner after a one-on-one with the goalkeeper.
77' Substitution. Ruben Neves makes way for Rafael Leao (Portugal).
77' The substitution is prepared. Jordan Ayew (Ghana) joins the action as a substitute, replacing Andre Ayew.
77' Otto Addo has decided to substitute Mohammed Kudus and he is replaced by Osman Bukari (Ghana).
73' 1 - 1
Andre Ayew (Ghana) received a delightful pass inside the box before slotting the ball past the goalkeeper. What a brilliant finish!
66' The referee signals that it is time for a substitution and Tariq Lamptey (Ghana) is coming onto the pitch as Alidu Seidu cannot continue after picking up an injury.
65' 1 - 0
GOAL! That’s a great strike from the spot by Cristiano Ronaldo (Portugal) into the left of the net, giving goalkeeper Lawrence Ati-Zigi no chance!
63' One of the Ghana players tripped an opponent and conceded a foul. The referee makes the call - penalty to Portugal!
57' Alidu Seidu (Ghana) takes his opponent down and receives a yellow card from the referee.
56' Otavio is being substituted because of an injury. Fernando Santos sends William Carvalho (Portugal) on the pitch.
49' Andre Ayew (Ghana) has tested the patience of referee Ismail Elfath and goes into the book for a previous late challenge.
46' The second half has just started.45+3' The referee blows his whistle to end the first half and the players are now heading to their respective dressing rooms.
45+1' Ismail Elfath shows a yellow card to Mohammed Kudus (Ghana) for his blatant foul.
31' The ball is in the net but it’s immediately ruled out by referee Ismail Elfath due to a foul, much to the disappointment of the Cristiano Ronaldo (Portugal) and his team.
1' We're underway!
Pre-match:
Portugal starting XI: Diogo Costa - Joao Cancelo, Ruben Dias, Danilo Pereira, Raphael Guerreiro - Ruben Neves, Bernardo Silva, Bruno Fernandes - Otavio, Cristiano Ronaldo, Joao Felix
Ghana starting XI: Lawrence Ati-Zigi - Alidu Seidu, Alexander Djiku, Daniel Amartey, Mohammed Salisu, Baba Rahman - Mohammed Kudus, Thomas Partey, Salis Abdul Samed, Andre Ayew - Inaki Williams
Players to watch: Portugal will be hoping the world’s most prolific international scorer Cristiano Ronaldo can put his former club drama behind him, as he aims to become the only player ever to score in five different FIFA World Cup tournaments. Meanwhile, Ghana’s influential Jordan Ayew will hope to be their good luck charm, having lost only once in 14 scoring appearances for his country (W12, D1).
Hot stat: The same half-time result has been replicated come full-time in 12 of Portugal’s last 15 matches.
World Cup trivia: This could be the last FIFA World Cup where a 32-team format is used, as the competition will be expanded to 48 teams from 2026.
