Townsend makes 14 changes as Scotland prepare for Portugal Test
Tom Jordan is the only player to retain his place from the side that started the 32-15 defeat against South Africa, while talismanic wing Darcy Graham returns to the side after missing the Boks game with a head injury.
Glasgow lock Alex Samuel and Edinburgh back-row forward Ben Muncaster will both win their first caps as members of the starting pack.
Freddy Douglas, the 19-year-old Edinburgh back-rower who has never played a competitive game at senior club level, is in line to make his debut off the bench.
Scotland (15-1)
Tom Jordan; Darcy Graham, Rory Hutchinson, Stafford McDowall (capt), Arron Reed; Adam Hastings, George Horne; Josh Bayliss, Ben Muncaster, Luke Crosbie; Alex Samuel, Alex Craig; Will Hurd, Patrick Harrison, Jamie Bhatti
Replacements: Johnny Matthews, Rory Sutherland, Elliot Millar Mills, Ewan Johnson, Freddy Douglas, Jamie Dobie, Matt Currie, Kyle Rowe
Coach: Gregor Townsend (SCO)