Saracens, who finished top of the standings in the regular season, had their noses in front for most of the game having led 20-18 at halftime after a penalty try and one for Max Malins.
Sale, seeking a second title in their first appearance in the final since their sole triumph in 2006, hit back strongly with three tries from Akker van der Merwe, Tom Roebuck and Bevan Rodd to edge ahead midway through the second half to threaten an upset.
Saracens, however, who lost to Leicester via a last-gasp drop goal in last year's final, delivered the telling blow with quickfire scores by Elliot Daly and Ivan van Zyl late in the second half to open a lead that Sale were unable to close.
Protesters invade pitch and briefly hold up final
The final was briefly held up when Just Stop Oil protesters invaded the pitch and released orange powder.
Three protesters ran onto the pitch 15 minutes into the match and, against a chorus of boos from the crowd, released powder in a similar fashion to their protest at the recent snooker world championship.
Stewards quickly removed the protesters and the game restarted after a delay of around five minutes.
