Wing Kyle Steyn has dropped out of the team with his wife in labour and due to give birth.
That has necessitated a move from full-back to wing for Kyle Rowe, with Paterson taking the latter's place in the side.
Paterson is a former junior international and has also played rugby sevens for the Scots.
The match in Edinburgh will kick off at 14:15 GMT.
Revised Scotland team
15-Harry Paterson, 14-Kyle Rowe, 13-Huw Jones, 12-Sione Tuipulotu, 11-Duhan van der Merwe, 10-Finn Russell (co-captain), 9-Ben White; 1-Pierre Schoeman, 2-George Turner, 3-Zander Fagerson, 4-Grant Gilchrist, 5-Scott Cummings, 6-Matt Fagerson, 7-Rory Darge (co-captain), 8-Jack Dempsey
Replacements: 16-Ewan Ashman, 17-Alec Hepburn, 18-Elliot Millar-Mills, 19-Sam Skinner, 20-Andy Christie, 21-George Horne, 22-Ben Healy, 23-Cameron Redpath
