Wales star North to retire from international rugby after Italy Test
North, who has won 120 caps, said on X, formerly known as Twitter, that it was the "right to time step away".
The 31-year-old, who has been recalled to the starting side for the wooden spoon clash in Cardiff, is second on Wales's all-time list of try-scorers with 47, behind Shane Williams (58).
"I've decided that the game on Saturday will bring my international career to an end," said North.
"After 14 years it feels like now is the right time to step away. I have loved and cherished every second in a Welsh shirt and been able to play alongside some fantastic team-mates."
"I've been very lucky to have lived my dream. I'm excited for the next chapter," he added.