Slade ruled out of England's Six Nations opener
Slade picked up the knock during Exeter's game against Castres last weekend and has not recovered sufficiently to be considered for selection, but Jamie George is included in the squad ahead of the Calcutta Cup clash at Twickenham.
The Saracens hooker was initially withdrawn from the group after he was concussed in their defeat to Edinburgh last weekend. He will continue to work through return-to-play protocols.
Anthony Watson has also been recalled following injury, the Rugby Football Union confirmed in a squad update issued on Sunday.
"This is a very important week for us as we prepare for our first game against Scotland," said England head coach Steve Borthwick, who confirmed his 36-man squad.
"We know that Scotland are an excellent side with a great coaching team led by Gregor Townsend. They're a settled squad who have been together a long time and have dominated this fixture in recent seasons.
"They will be coming to Twickenham full of confidence. We know we have a lot of work to do. The team trained very hard last week and are ready to go again this week."
