Ten Hag: Rashford dropped against Wolves for 'disciplinary' reasons
United manager Erik ten Hag revealed during a pre-match television interview that Rashford had been axed for the game.
The 25-year-old had been in good club form this season, scoring in each of United's last two games, including a fine individual effort in the League Cup fourth-round win over Burnley last week.
Rashford also scored three goals for England at the World Cup, where Gareth Southgate's men reached the quarter-finals.
However, Rashford was not included in the United starting line-up at Molineux on Saturday as Alejandro Garnacho came into the side as the only change from the win over Nottingham Forest.
Ten Hag would not give any further details when pressed on the decision to drop Rashford during his pre-match interview with BT Sport, adding only it was "our rules".
United will be looking to extend a four-match winning run in all competitions, while Wolves are aiming to climb out of the relegation zone.