Reigning champion Medvedev joins Nadal in withdrawing from Qatar Open
The Russian has not played since losing to Jannik Sinner in the Australian Open final last month.
"Unfortunately, I am not able to defend my title in Doha this year. I am still not 100 per cent ready to compete," the 2021 US Open champion said on Instagram.
"I am very sorry for the tournament, the fans, and the sponsors of the event who have always treated me so well when I was in Doha. I love playing in Doha and look forward to coming back in the future."
Medvedev beat Andy Murray in last year's final.
Spaniard Rafa Nadal also pulled out of the ATP 250 tournament, which will be held in Doha from February 19th-24th, as the 22-time Grand Slam champion continues to struggle with injury.