With Centre Court still filling up following Alcaraz's 6-7(1), 6-3, 6-4, 6-4 victory over fifth seed Daniil Medvedev a short while earlier, second seed Djokovic broke after a breathtaking 26-shot rally in the sixth game of the opening set.
He raised his arms and demanded more from the crowd, but that only spurred Musetti into action as the Italian broke back for 4-5 with a bullet forehand - only to gift the set to his opponent after a shaky service game.
Musetti quickly made amends and inroads in the second set, producing a stunning backhand pass for a 3-1 lead, but Djokovic was unperturbed as he clawed his way back and raised his level significantly at the end to clinch the tiebreak.
With a sixth straight All England Club final and his first of an unusually patchy season within sight, the 24-times Grand Slam champion pounced for a break in the opening game of the third set with a backhand crosscourt winner.
Djokovic mixed up his game by serving and volleying to leave Musetti on the ropes, before staving off a late comeback attempt from the Italian to save a breakpoint and prevail on his fourth match point when the Italian sent a shot long.
